Sequence Fails to Open

iMac late 2014
32GB RAM
High Sierra
MC 8.5.3

I am suddenly unable to open a sequence created on Monday,on my work PC system.

I brought media and project home.
Today, opening it on my home system causes Avid to crash.
Re-indexed media, duplicated sequence, deleted MC State, then created new project
to import and open it. No go, each time.

I am out of the typical approaches, any suggestions?